Malaria aquaporin-4
WebJan 15, 2013 · Expression and cellular localization of the brain water channel aquaporin-4 (AQP4) was investigated during the neurological syndrome. Semiquantitative real … WebSep 9, 2015 · Involvement of aquaporins in multiple clinical states is becoming recognized—renal concentration, fluid retention, blindness, skin hydration, brain edema, thermal stress, glucose homeostasis, malaria, and even arsenic poisoning. Aquaporins are particularly important in plant biology.
Malaria aquaporin-4
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WebQuantitation of brain edema and localisation of aquaporin 4 ... EN. English Deutsch Français Español Português Italiano Român Nederlands Latina Dansk Svenska Norsk Magyar Bahasa Indonesia Türkçe Suomi Latvian Lithuanian česk ... WebMar 15, 2024 · Malaria remains a devastating disease and, with current measures failing to control its transmission, there is a need for novel interventions. A family of proteins that have long been pursued as potential intervention targets are aquaporins which are channels facilitating the movement of water and other solutes across membranes. We identify a …
WebAquaporin Water Channels: From Atomic Structure to Malaria. Aquaporin (AQP) water channel proteins confer high water permeability to many biological membranes. …
The condition known as neuromyelitis optica, NMO, is a rare demyelinating, inflammatory disorder of the CNS that primarily affects the optic nerves and spinal cord of individuals. Aquaporin-4 is the predominant autoimmune target in 2/3 neuromyelitis optica and higher AQP4 autoantibody levels are associated with the occurrence of optic neuritis (ON), however serum AQP4-IgG titer only moderately reflects disease activity, severity, or neurological prognosis. Specific AQP4 IgG autoa… WebFeb 12, 2024 · Apoptotic changes and aquaporin-1 expression in the choroid plexus of cerebral malaria patients Apoptotic changes and altered AQP-1 expression may contribute to CPEC dysfunction and subsequently reduce cerebrospinal fluid production, affecting the water homeostasis in the brains of patients with CM.
WebBrain edema, aquaporin 4 expression and cerebral malaria. Figure 3. Leukocyte sequestration in brain microvessels and its relation to edema during PbA infection. A. Individual. microvessels were analysed in 15 mice per group. 518 and 398 vessels were studied in CBA and BALB/c mice, respectively.. Mann-Whitney test. B. Proportion of …
WebOne such plausible target in Plasmodium falciparum is Aquaporin. 51 The aquaporins belong to a family of small (24-30 kDa) pore-forming integral 52 membrane proteins that act … lightroom 5 new featuresWebFor the past ten years Peter Agre’s lab has focused upon the role of aquaporins in malaria. As Director of the Johns Hopkins Malaria Research Institute, he serves as Program Director of the International Center of Excellence for Malaria Research in Zimbabwe and Zambia. In 2024, malaria afflicted 247 million people globally and killed approximately … Website Feedback - Peter Agre, MD - Leadership - About Us - Johns Hopkins … peanuts as medicineWebJul 23, 2011 · We show a dramatic aquaporin 4 (AQP4) upregulation, selectively at the level of astrocytic foot processes, in both CM and non-CM disease, but significantly more pronounced in mice with malarial-induced neurological syndrome. peanuts as functional food: a reviewWebEdited* by Peter Agre, Johns Hopkins Malaria Research Institute, Baltimore, MD, and approved December 27, 2010 (received for review September 1, 2010) January 24, 2011. ... Here we show that a complex containing aquaporin-4 (AQP4) and transient receptor potential vanilloid 4 (TRPV4) is essential for RVD in astrocytes. ... lightroom 5 patcherWebAquaporin (AQP) water channels are found throughout nature and confer high-capacity water flow through cell membranes. The genome of the major malaria vector mosquito … peanuts association limogesWebAqp4 Gene Detail Summary Symbol Aqp4 Name aquaporin 4 Synonyms aquaporin-4 Feature Type protein coding gene IDs MGI:107387 NCBI Gene: 11829 Alliance gene … peanuts artwork for saleWebAquaporins are transmembrane channels that facilitate the permeation of water and small, uncharged amphipathic molecules across cellular membranes. One distinct aquaporin subfamily contains pure water channels, whereas a second subfamily contains ... Johns Hopkins Malaria Research Institute, Baltimore, MD, and approved August 10, 2010 … lightroom 5 on workstation with xeon